Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment ..
E-mycin, erythrocin), telithromycin (ketek), any other medications, or any of the ingredients in clarithromycin tablets or suspension ..
This may result in sub-therapeutic levels of clarithromycin leading to reduced efficacy ..
Clarithromycin comes as a tablet, an extended-release (long-acting) tablet, and a suspension (liquid) to take by mouth ..
If you become pregnant while taking clarithromycin, call your doctor. Clarithromycin must not be given to patients with hypokalaemia (see section 4 ..
Concomitant administration of clarithromycin with astemizole, cisapride, pimozide and terfenadine is contraindicated (see section 4 ..
As part of fdas usual ongoing safety monitoring of drugs, we are continuing to monitor safety reports in patients taking clarithromycin. As with other strong cyp3a4 inhibitors, clarithromycin should not be used in patients taking colchicine. This medication may be prescribed for other uses ask your doctor or pharmacist for more information.
Concomitant administration of clarithromycin and ergotamine or dihydroergotamine is contraindicated, as this may result in ergot toxicity. Caution is advised regarding concomitant administration of clarithromycin and triazolobenzodiazepines, such as triazolam, and midazolam (see section 4. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
In situations where the concomitant use of clarithromycin with statins cannot be avoided, it is recommended to prescribe the lowest registered dose of the statin. Clarithromycin should not be given to patients with history of qt prolongation (congenital or documented acquired qt prolongation) or ventricular cardiac arrhythmia, including torsades de pointe (see sections 4. Concomitant use of clarithromycin with lovastatin or simvastatin is contraindicated (see 4.
Clarithromycin is contraindicated in patients with known hypersensitivity to macrolide antibiotic drugs or any of its excipients listed in section 6. The following drugs are known or suspected to affect circulating concentrations of clarithromycin clarithromycin dosage adjustment or consideration of alternative treatments may be required. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital.
In the event of severe acute hypersensitivity reactions, such as anaphylaxis, severe cutaneous adverse reactions (scar) (e. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. A pharmacokinetic study demonstrated that the concomitant administration of ritonavir 200 mg every eight hours and clarithromycin 500 mg every 12 hours resulted in a marked inhibition of the metabolism of clarithromycin.
This may result in sub-therapeutic levels of clarithromycin leading to reduced efficacy. Some observational studies have identified a rare short term risk of arrhythmia, myocardial infarction and cardiovascular mortality associated with macrolides including clarithromycin. Microbial testing should be performed and adequate treatment initiated. When suggestions are available use up and down arrows to review and enter to select. Patients should be monitored for signs and symptoms of myopathy.
Since the microbiological activities of clarithromycin and 14-oh-clarithromycin are different for different bacteria, the intended therapeutic effect could be impaired during concomitant administration of clarithromycin and enzyme inducers. A pharmacokinetic study demonstrated that the concomitant administration of ritonavir 200 mg every eight hours and clarithromycin 500 mg every 12 hours resulted in a marked inhibition of the metabolism of clarithromycin. If the victim has collapsed, had a seizure, has trouble breathing, or cant be awakened, immediately call emergency services at 911. The long-acting tablet is usually taken with food every 24 hours (once a day) for 7 to 14 days. Macrolides have been reported to alter the metabolism of terfenadine resulting in increased levels of terfenadine which has occasionally been associated with cardiac arrhythmias such as qt prolongation, ventricular tachycardia, ventricular fibrillation and torsades de pointes (see section 4.
It is used in combination with other medications to eliminate , a bacterium that causes ulcers. Concomitant administration of clarithromycin and these medicinal products is contraindicated (see section 4. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. It slowly releases the medication as it passes through your digestive system. However, you should not flush this medication down the toilet.